Concanavalin A Inhibition of Tissue Factor (Thromboplastin) Activity

Concanavalin A inhibition of tissue factor (thromboplastin) activity.

Reduction of salivary tissue factor (thromboplastin) activity by warfarin therapy.

The coagulant of normal human saliva has been identified as tissue factor (thromboplastin, TF) by virtue of its ability to cause rapid coagulation in plasmas deficient in first-stage coagulation factors and to activate factor x in the presence of factor VII and by virtue of the fact that its activity is expressed only in the presence of factor VII and is inhibited by an antibody to TF. The TF i...

Thromboplastin (tissue factor) in plasma membranes of human monocytes.

The synthesis of thromboplastin, a potent trigger of blood coagulation, can be induced in human peripheral blood monocytes. Indirect evidence suggests that newly synthesized thromboplastin becomes in part available on the cell surface. We have attempted to study the localization and availability of thromboplastin more directly by isolating plasma membranes from isolated human peripheral blood m...

Membrane-mediated synthesis of tissue factor (thromboplastin) in cultured fibroblasts.

A potent procoagulant synthesized by mycin. Tissue factor production is related cultured human skin fibroblasts has been to the shape change that occurs as the identified as tissue factor (factor Iii, thromcells spread on the floor of the culture boplastin), since it binds factor VII and is vessel, but tissue factor is not synonymous blocked by a specific antitissue factor with the configuratio...

Immunologic identification of tissue factor (thromboplastin) synthesized by cultured fibroblasts.

Immunologic methods were employed in an attempt to identify a potent procoagulant present in homogenates of human skin fibroblasts cultured in vitro. The activity of this procoagulant was restricted to the early stages of coagulation and was heretofore considered to be due to tissue factor (tissue thromboplastin, factor Ill) either alone or in combination with one or more of the first-stage coa...